The integrative biology of type 2 diabetes
M Roden, GI Shulman - Nature, 2019 - nature.com
Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …
Metabolically healthy obesity: facts and fantasies
Although obesity is typically associated with metabolic dysfunction and cardiometabolic
diseases, some people with obesity are protected from many of the adverse metabolic …
diseases, some people with obesity are protected from many of the adverse metabolic …
Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity
Mitochondrial function in white adipose tissue (WAT) is an important yet understudied aspect
of adipocyte biology. Here, we report a role for amyloid precursor protein (APP) in …
of adipocyte biology. Here, we report a role for amyloid precursor protein (APP) in …
Fundamental roles for hypoxia signalling in adipose tissue metabolism and inflammation in obesity
Z Michailidou - Current Opinion in Physiology, 2019 - Elsevier
Over a decade ago the notion that adipose tissue could become hypoxic during adipose
expansion with obesity was proposed. A series of elegant studies in mouse models of …
expansion with obesity was proposed. A series of elegant studies in mouse models of …
Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation
YS Lee, M Riopel, P Cabrales, GK Bandyopadhyay - Science advances, 2019 - science.org
The decrease in incretin effects is an important etiologic component of type 2 diabetes with
unknown mechanisms. In an attempt to understand obesity-induced changes in liver oxygen …
unknown mechanisms. In an attempt to understand obesity-induced changes in liver oxygen …
ANT2 mediates hypoxia and inflammation in obesity
I Leake - Nature Reviews. Endocrinology, 2019 - search.proquest.com
www. nature. com/nrendo activation is important not only for the initiation of obesity-induced
adipose tissue hypoxia, but also for the maintenance of obesity-induced metabolic …
adipose tissue hypoxia, but also for the maintenance of obesity-induced metabolic …
[HTML][HTML] 偏头痛慢性转化的临床危险因素分析
乌欣蔚， 罗龙， 杨晓苏 - Journal of International Neurology and …, 2019 - html.rhhz.net
目的比较慢性偏头痛(CM) 与发作性偏头痛(EM) 的病史特征, 临床特点等,
探究偏头痛慢性转化的危险因素, 为其防治提供依据和策略. 方法共纳入在中南大学湘雅医院 …
探究偏头痛慢性转化的危险因素, 为其防治提供依据和策略. 方法共纳入在中南大学湘雅医院 …