A systematic review and standardized clinical validity assessment of male infertility genes
MS Oud, L Volozonoka, RM Smits… - Human …, 2019 - academic.oup.com
STUDY QUESTION Which genes are confidently linked to human monogenic male
infertility? SUMMARY ANSWER Our systematic literature search and clinical validity …
infertility? SUMMARY ANSWER Our systematic literature search and clinical validity …
[HTML][HTML] De novo mutations reflect development and aging of the human germline
JM Goldmann, JA Veltman, C Gilissen - Trends in Genetics, 2019 - cell.com
Human germline de novo mutations (DNMs) are both a driver of evolution and an important
cause of genetic diseases. In the past few years, whole-genome sequencing (WGS) of …
cause of genetic diseases. In the past few years, whole-genome sequencing (WGS) of …
[PDF][PDF] The neonatal and adult human testis defined at the single-cell level
Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
[HTML][HTML] Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …
series of developmental transitions that are poorly characterised at the molecular level …
Single-Cell Signature Explorer for comprehensive visualization of single cell signatures across scRNA-seq datasets
F Pont, M Tosolini, JJ Fournié - Nucleic acids research, 2019 - academic.oup.com
The momentum of scRNA-seq datasets prompts for simple and powerful tools exploring their
meaningful signatures. Here we present Single-Cell_Signature_Explorer (https://sites …
meaningful signatures. Here we present Single-Cell_Signature_Explorer (https://sites …
Spermatogonial stem cells: updates from specification to clinical relevance
Human spermatogonia are target for exploration of adult stem cell characteristics and
potential source for the development of therapeutic applications. Almost 50 years ago, Yves …
potential source for the development of therapeutic applications. Almost 50 years ago, Yves …
Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ cell depletion
Mammalian spermatogenesis is a highly complex multi-step process sustained by a
population of mitotic germ cells with self-renewal potential known as spermatogonial stem …
population of mitotic germ cells with self-renewal potential known as spermatogonial stem …
[HTML][HTML] Human germline cell development: from the perspective of single-cell sequencing
L Wen, F Tang - Molecular cell, 2019 - cell.com
Germline cells are the beginning of new individuals in multicellular animals, including
humans. Our understanding of these cell types is limited by the difficulty of analyzing the …
humans. Our understanding of these cell types is limited by the difficulty of analyzing the …
What has single-cell RNA-seq taught us about mammalian spermatogenesis?
S Suzuki, VD Diaz, BP Hermann - Biology of Reproduction, 2019 - academic.oup.com
Mammalian spermatogenesis is a complex developmental program that transforms mitotic
testicular germ cells (spermatogonia) into mature male gametes (sperm) for production of …
testicular germ cells (spermatogonia) into mature male gametes (sperm) for production of …