Long non-coding RNA in the pathogenesis of cancers

Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

Global positioning system: understanding long noncoding RNAs through subcellular localization

J Carlevaro-Fita, R Johnson - Molecular cell, 2019 - cell.com
The localization of long noncoding RNAs (lncRNAs) within the cell is the primary
determinant of their molecular functions. LncRNAs are often thought of as chromatin …

Roles and regulation of long noncoding RNAs in hepatocellular carcinoma

LJ Lim, SYS Wong, F Huang, S Lim, SS Chong, LL Ooi… - Cancer Research, 2019 - AACR
Next-generation sequencing has uncovered thousands of long noncoding RNAs (lncRNA).
Many are reported to be aberrantly expressed in various cancers, including hepatocellular …

Molecular mechanisms of TUG1 in the proliferation, apoptosis, migration and invasion of cancer cells

H Zhou, L Sun, F Wan - Oncology letters, 2019 - spandidos-publications.com
Long non‑coding RNAs (lncRNAs) are RNA sequences> 200 nucleotides in length that have
no protein‑coding capacity. lncRNAs serve key roles in multiple biological processes, such …

LncRNA AFAP1-AS1 supresses miR-139-5p and promotes cell proliferation and chemotherapy resistance of non-small cell lung cancer by competitively upregulating …

N Huang, W Guo, K Ren, W Li, Y Jiang, J Sun… - Frontiers in …, 2019 - frontiersin.org
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death
worldwide. This study aims to understand the underlying mechanism of lncRNA, actin …

Long noncoding RNA LCAT1 functions as a ceRNA to regulate RAC1 function by sponging miR-4715-5p in lung cancer

J Yang, Q Qiu, X Qian, J Yi, Y Jiao, M Yu, X Li, J Li… - Molecular cancer, 2019 - Springer
Abstract Introduction Long noncoding RNAs (lncRNAs) are emerging as key players in the
development and progression of cancer. However, the biological role and clinical …

KLF5 regulated lncRNA RP1 promotes the growth and metastasis of breast cancer via repressing p27kip1 translation

X Jia, L Shi, X Wang, L Luo, L Ling, J Yin, Y Song… - Cell death & …, 2019 - nature.com
Increasing evidence suggest that lncRNAs (long noncoding RNAs) play important roles in
human cancer. Breast cancer is a heterogeneous disease and the potential involvement of …

[HTML][HTML] Long non-coding RNA TUG1 mediates 5-fluorouracil resistance by acting as a ceRNA of miR-197-3p in colorectal cancer

M Wang, H Hu, Y Wang, Q Huang, R Huang… - Journal of …, 2019 - ncbi.nlm.nih.gov
One major reason for the failure of advanced colorectal cancer (CRC) treatment is the
occurrence of chemoresistance to fluoropyrimidine (Fu)-based chemotherapy. Accumulating …

The role of lncRNAs in the distant metastasis of breast cancer

Y Wu, A Shao, L Wang, K Hu, C Yu, C Pan… - Frontiers in …, 2019 - frontiersin.org
Breast cancer (BC) remains the most frequently diagnosed cancer worldwide. Among breast
cancer patients, distant metastasis and invasion is the leading cause of BC related death …

Low long noncoding RNA growth arrest‐specific transcript 5 expression in the exosomes of lung cancer cells promotes tumor angiogenesis

Y Cheng, X Dai, T Yang, N Zhang, Z Liu… - Journal of …, 2019 - Wiley Online Library
Angiogenesis plays a key role in the development and progression of lung cancer. Recent
studies have found that tumor cells can stimulate angiogenesis by secreting exosomes …