Microfluidics‐based biomaterials and biodevices

R Dong, Y Liu, L Mou, J Deng, X Jiang - Advanced Materials, 2019 - Wiley Online Library
The rapid development of microfluidics technology has promoted new innovations in
materials science, particularly by interacting with biological systems, based on precise …

Engineered models to parse apart the metastatic cascade

LA Hapach, JA Mosier, W Wang… - NPJ precision …, 2019 - nature.com
While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …

Microfabricated blood vessels for modeling the vascular transport barrier

WJ Polacheck, ML Kutys, JB Tefft, CS Chen - Nature protocols, 2019 - nature.com
The vascular endothelium forms the inner lining of blood vessels and actively regulates
vascular permeability in response to chemical and physical stimuli. Understanding the …

Epstein− Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas

E Anastasiadou, D Stroopinsky, S Alimperti, AL Jiao… - Leukemia, 2019 - nature.com
Cancer cells subvert host immune surveillance by altering immune checkpoint (IC) proteins.
Some Epstein− Barr virus (EBV)-associated tumors have higher Programmed Cell Death …

Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D

JJ Jamieson, RM Linville, YY Ding, S Gerecht… - Fluids and Barriers of …, 2019 - Springer
Background Pericytes of the blood–brain barrier (BBB) are embedded within basement
membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet …

Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing

K Gold, AK Gaharwar, A Jain - Biomaterials, 2019 - Elsevier
Most biomedical and pharmaceutical research of the human vascular system aims to
unravel the complex mechanisms that drive disease progression from molecular to organ …

Endothelial cell mechanotransduction in the dynamic vascular environment

FW Charbonier, M Zamani, NF Huang - Advanced biosystems, 2019 - Wiley Online Library
The endothelial cells (ECs) that line the inner layer of blood vessels are responsible for
maintaining vascular homeostasis under physiological conditions. In the presence of …

Pericytes contribute to dysfunction in a human 3D model of placental microvasculature through VEGF‐Ang‐Tie2 signaling

K Haase, MR Gillrie, C Hajal, RD Kamm - Advanced Science, 2019 - Wiley Online Library
Placental vasculopathies are associated with a number of pregnancy‐related diseases,
including pre‐eclampsia (PE)—a leading cause of maternal–fetal morbidity and mortality …

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

K Kruse, QS Lee, Y Sun, J Klomp, X Yang… - Journal of Cell …, 2019 - rupress.org
Vascular endothelial (VE)–cadherin forms homotypic adherens junctions (AJs) in the
endothelium, whereas N-cadherin forms heterotypic adhesion between endothelial cells …

Comparison of organ-specific endothelial cells in terms of microvascular formation and endothelial barrier functions

H Uwamori, Y Ono, T Yamashita, K Arai, R Sudo - Microvascular research, 2019 - Elsevier
Every organ demonstrates specific vascular characteristics and functions maintained by
interactions of endothelial cells (ECs) and parenchymal cells. Particularly, brain ECs play a …