Microfluidics‐based biomaterials and biodevices
The rapid development of microfluidics technology has promoted new innovations in
materials science, particularly by interacting with biological systems, based on precise …
materials science, particularly by interacting with biological systems, based on precise …
Engineered models to parse apart the metastatic cascade
While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …
Microfabricated blood vessels for modeling the vascular transport barrier
The vascular endothelium forms the inner lining of blood vessels and actively regulates
vascular permeability in response to chemical and physical stimuli. Understanding the …
vascular permeability in response to chemical and physical stimuli. Understanding the …
Epstein− Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas
Cancer cells subvert host immune surveillance by altering immune checkpoint (IC) proteins.
Some Epstein− Barr virus (EBV)-associated tumors have higher Programmed Cell Death …
Some Epstein− Barr virus (EBV)-associated tumors have higher Programmed Cell Death …
Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D
Background Pericytes of the blood–brain barrier (BBB) are embedded within basement
membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet …
membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet …
Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing
K Gold, AK Gaharwar, A Jain - Biomaterials, 2019 - Elsevier
Most biomedical and pharmaceutical research of the human vascular system aims to
unravel the complex mechanisms that drive disease progression from molecular to organ …
unravel the complex mechanisms that drive disease progression from molecular to organ …
Endothelial cell mechanotransduction in the dynamic vascular environment
The endothelial cells (ECs) that line the inner layer of blood vessels are responsible for
maintaining vascular homeostasis under physiological conditions. In the presence of …
maintaining vascular homeostasis under physiological conditions. In the presence of …
Pericytes contribute to dysfunction in a human 3D model of placental microvasculature through VEGF‐Ang‐Tie2 signaling
Placental vasculopathies are associated with a number of pregnancy‐related diseases,
including pre‐eclampsia (PE)—a leading cause of maternal–fetal morbidity and mortality …
including pre‐eclampsia (PE)—a leading cause of maternal–fetal morbidity and mortality …
N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability
Vascular endothelial (VE)–cadherin forms homotypic adherens junctions (AJs) in the
endothelium, whereas N-cadherin forms heterotypic adhesion between endothelial cells …
endothelium, whereas N-cadherin forms heterotypic adhesion between endothelial cells …
Comparison of organ-specific endothelial cells in terms of microvascular formation and endothelial barrier functions
H Uwamori, Y Ono, T Yamashita, K Arai, R Sudo - Microvascular research, 2019 - Elsevier
Every organ demonstrates specific vascular characteristics and functions maintained by
interactions of endothelial cells (ECs) and parenchymal cells. Particularly, brain ECs play a …
interactions of endothelial cells (ECs) and parenchymal cells. Particularly, brain ECs play a …