Balancing STAT activity as a therapeutic strategy
KL Polak, NM Chernosky, JM Smigiel, I Tamagno… - Cancers, 2019 - mdpi.com
Driven by dysregulated IL-6 family member cytokine signaling in the tumor
microenvironment (TME), aberrant signal transducer and activator of transcription (STAT3) …
microenvironment (TME), aberrant signal transducer and activator of transcription (STAT3) …
Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets
Bone marrow megakaryocytes engulf neutrophils in a phenomenon termed emperipolesis.
We show here that emperipolesis is a dynamic process mediated actively by both lineages …
We show here that emperipolesis is a dynamic process mediated actively by both lineages …
STAT3 rs4796793 contributes to lung cancer risk and clinical outcomes of platinum-based chemotherapy
WJ Gong, LY Ma, L Hu, YN Lv, H Huang, JQ Xu… - International Journal of …, 2019 - Springer
Background Signal transducer and activator of transcription (STAT) 3 plays a vital role in
carcinogenesis and drug response. Platinum-based chemotherapy is the first-line treatment …
carcinogenesis and drug response. Platinum-based chemotherapy is the first-line treatment …