Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

S Sureshchandra, NE Marshall… - Journal of leukocyte …, 2019 - academic.oup.com
Maternal pregravid obesity results in several adverse health outcomes during pregnancy,
including increased risk of gestational diabetes, preeclampsia, placental abruption, and …

Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth

JS Son, X Liu, Q Tian, L Zhao, Y Chen… - The Journal of …, 2019 - Wiley Online Library
Key points Maternal exercise improves the metabolic health of maternal mice challenged
with a high‐fat diet. Exercise intervention of obese mothers prevents fetal overgrowth …

Insulin stimulates GLUT4 trafficking to the syncytiotrophoblast basal plasma membrane in the human placenta

LB James-Allan, J Arbet, SB Teal… - The Journal of …, 2019 - academic.oup.com
Context Placental transport capacity influences fetal glucose supply. The syncytiotrophoblast
is the transporting epithelium in the human placenta, expressing glucose transporters …

Uteroplacental glucose uptake and fetal glucose consumption: a quantitative study in human pregnancies

TM Michelsen, AM Holme, MB Holm… - The Journal of …, 2019 - academic.oup.com
Context Maternal glucose levels and body mass index (BMI) are determinants of fetal
overgrowth, but their relation to fetal glucose consumption is not well characterized in …

[HTML][HTML] Pre-pregnancy underweight and obesity are positively associated with small-for-gestational-age infants in a Chinese population

YH Chen, L Li, W Chen, ZB Liu, L Ma, XX Gao, JL He… - Scientific reports, 2019 - nature.com
The association between suboptimal pre-pregnancy body mass index (BMI) and small-for-
gestational-age (SGA) infants is not well defined. We investigated the association between …

[HTML][HTML] Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring

ME Paulsen, FJ Rosario, SR Wesolowski… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Infants of obese mothers have an increased risk of developing obesity, insulin resistance,
and type 2 diabetes. The underlying mechanisms remain elusive, and no effective …

Analysis of correlations between the placental expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 and selected maternal and fetal parameters in …

PJ Stanirowski, D Szukiewicz, M Pyzlak… - The Journal of …, 2019 - Taylor & Francis
Purpose: The aim of the study was to analyze the correlations between the expression of
glucose transporters GLUT-1, GLUT-4, and GLUT-9 in human term placenta and selected …

No evidence of attenuation of placental insulin-stimulated Akt phosphorylation and amino acid transport in maternal obesity and gestational diabetes mellitus

M Castillo-Castrejon, T Jansson… - American Journal of …, 2019 - journals.physiology.org
Pregnancies complicated by obesity and/or gestational diabetes (GDM) are associated with
peripheral insulin resistance; however, the insulin responsiveness of the placenta in these …

Insulin-dependent, glucose transporter 1 mediated glucose uptake and tube formation in the human placental first trimester trophoblast cells

S Basak, S Vilasagaram, K Naidu… - Molecular and Cellular …, 2019 - Springer
During early gestation, hypoxic condition is critically maintained by optimal glucose
metabolism and transporter activities. Glucose is readily available energy nutrient required …

[HTML][HTML] Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy

C Kappen, C Kruger, S Jones, NJ Herion… - PLoS One, 2019 - journals.plos.org
Diabetes in the mother during pregnancy is a risk factor for birth defects and perinatal
complications and can affect long-term health of the offspring through developmental …