The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

As a major component of cell membrane lipids, Arachidonic acid (AA), being a major
component of the cell membrane lipid content, is mainly metabolized by three kinds of …

Eicosapentaenoic acid (EPA) is a key anti-inflammatory/anti-aggregatory long-chain
polyunsaturated omega-3 fatty acid. Conversely, the omega-6 fatty acid, arachidonic acid …

In this review we examine the effects of both over-and under-production of heme oxygenase-
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …

Epilepsy is a neurological disorder that affects approximately 50 million people worldwide.
There is currently no definitive epilepsy cure. However, in recent years, medicinal cannabis …

We are all too familiar with the events that follow a bee sting—heat, redness, swelling, and
pain. These are Celsus' four cardinal signs of inflammation that are driven by very well …

Chemotherapy, nerve injuries, or diseases like multiple sclerosis can cause
pathophysiological processes of persistent and neuropathic pain. Thereby, the activation …

Colon cancer is the third most common cancer and the second leading cause of cancer-
related death in the United States, emphasizing the need for the discovery of new cellular …

Epoxyeicosatrienoic acids (EETs) are also known as epoxyeicosanoids that have renal and
cardiovascular actions. These renal and cardiovascular actions can be regulated by soluble …

Neuroinflammation is a physiologic response aimed at protecting the central nervous system
during injury. However, unresolved and chronic neuroinflammation can lead to long term …