Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by
the hypothalamus. The main biological actions of orexins, focused on the central nervous …

In this review, we outline the role of orexin receptor antagonists in disorders of sleep/wake
and other potential neuropsychiatric conditions, with a focus on suvorexant, which is …

Excessive arousal has a role in the pathophysiology of major depressive disorder (MDD).
Seltorexant (JNJ-42847922/MIN-202) is a selective antagonist of the human orexin-2 …

Background: Insomnia is common in patients with major depressive disorder. Although
antidepressants improve mood, insomnia often persists as a result of physiological …

Abstract Study Objectives To present results from in vivo studies underlying the preclinical
development of lemborexant (E2006), a novel dual orexin (hypocretin) receptor antagonist …

Abstract Sphingosine 1-phosphate (S1P) receptors (nomenclature as agreed by the NC-
IUPHAR Subcommittee on Lysophospholipid receptors [70]) are activated by the …

The orexin system plays an important role in the regulation of wakefulness. Suvorexant, a
dual orexin receptor antagonist (DORA) is approved for the treatment of primary insomnia …

Obesity is increasing at epidemic proportions both in children and adults posing a big public
health problem among children as well as adults. With parallel increase in comorbidities like …

The diversity of G protein-coupled receptors is a fundamental element in this thesis. GPCRs
are the largest family of membrane proteins, with about 800 in humans. While the human …

Neuropeptide and chemokine receptors of the G protein-coupled receptor (GPCR) family
belong to different classes and subgroups providing different docking sites and special …