Upon activation, naïve CD4+ T cells differentiate into a number of specialized T helper (Th)
cell subsets. Th2 cells are central players in immunity to helminths and are implicated in …

The gastrointestinal mucosa is critical for maintaining the integrity and functions of the gut.
Disruption of this barrier is a hallmark and a risk factor for many intestinal and chronic …

Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes
in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis …

Macrophages undergo metabolic changes during activation that are coupled to functional
responses. The gram negative bacterial product lipopolysaccharide (LPS) is especially …

Metabolic pathways that regulate T-cell function show promise as therapeutic targets in
diverse diseases. Here, we show that at rest cultured human effector memory and central …

T cells play important roles in autoimmune diseases and cancer. Following the cloning of the
T cell receptor (TCR), the race was on to map signaling proteins that contributed to T cell …

RNA-binding proteins (RBPs) regulate fundamental processes, such as differentiation and
self-renewal, by enabling the dynamic control of protein abundance or isoforms or through …

Objectives The gene encoding glucose transporter 3 (GLUT3, SLC2A3) is present in the
human population at variable copy number. An overt disease phenotype of SLC2A3 copy …

The evaluation of glucose metabolic activity in immune cells is becoming an increasingly
standard task in immunological research. In this study, we described a sensitive …

The simultaneous quantification of protein and RNA makes possible the inference of past,
present and future cell states from single experimental snapshots. To enable such temporal …