The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …

Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

The onset of puberty in adolescents and whether it is related to obesity is an ongoing topic
for debate. Epidemiological cross-sectional and longitudinal studies show a shift towards …

Body fat mass increases when energy intake exceeds energy expenditure. In the long term,
a positive energy balance will result in obesity. The worldwide prevalence of obesity has …

The blood–brain barrier (BBB) was first noted for its ability to prevent the unregulated
exchange of substances between the blood and the central nervous system (CNS). Over …

Leptin informs the brain about sufficiency of fuel stores. When insufficient, leptin levels fall,
triggering compensatory increases in appetite. Falling leptin is first sensed by hypothalamic …

Background: Exercise is a reinforcing behavior and finding exercise highly reinforcing is
characteristic of habitual exercisers. Genotypes related to dopamine metabolism moderate …

Leptin regulates energy balance and also exhibits neurotrophic effects during critical
developmental periods. However, the actual role of leptin during development is not yet fully …