The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and
adaptive immune systems, mediating inflammation in response to a wide range of stimuli …

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Interleukin (IL)-33 belongs to IL-1 cytokine family which is constitutively produced from the
structural and lining cells including fibroblasts, endothelial cells, and epithelial cells of skin …

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed
to identity novel genetic variants associated with moderate-to-severe asthma, see whether …

Clinical observations implicate a role of eosinophils in cardiovascular diseases because
markers of eosinophil activation are elevated in atherosclerosis and thrombosis. However …

Respiratory infections are common precursors to asthma exacerbations in children, but
molecular immune responses that determine whether and how an infection causes an …

Interleukin 33 (IL-33) is an alarmin cytokine from the IL-1 family. IL-33 is localized in the
nucleus and acts there as a gene regulator. Following injury, stress or cell death, it is …

Introduction: Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe
asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma …

Asthma is a common complex disease of the airways. Genome-wide association studies
(GWASs) of asthma have identified many risk alleles and loci that have been replicated in …