Eukaryotic cells must fit meters of DNA into micron-sized cell nuclei and, at the same time,
control and modulate the access to the genetic material. The necessary amount of DNA …

Nucleosomes are fundamental units of chromatin compaction, which organize∼ 200 DNA
base pairs using an octamer of histone proteins. Their ubiquitous presence in the cell …

Meters of DNA wrap around histone proteins to form nucleosomes and fit inside the micron-
diameter nucleus. For the genetic information encoded in the DNA to become available for …

Nucleosomes are the fundamental building blocks of chromatin that regulate DNA access
and are composed of histone octamers. ATP-dependent chromatin remodelers like ISW2 …

Nucleosomes represent the elementary units of chromatin packing and hubs in epigenetic
signaling pathways. Across the chromatin and over the lifetime of the eukaryotic cell …

The DNA of eukaryotic chromatin and chromosomes is repeatedly supercoiled around
histone octamers forming 'beads-on-a-string'chains of nucleosomes. The extent of …

Eukaryotic genome is packaged in a nucleus in the form of chromatin. The fundamental
structural unit of the chromatin is the protein-DNA complex, nucleosome, where DNA of …

The N-terminal regions (tails) of histone proteins are dynamic elements that protrude from
the nucleosome and are involved in many aspects of chromatin organization. Their …

Chromatin compaction is a process of fundamental importance in Biology, as it greatly
influences cellular function and gene expression. The dynamics of compaction is …

Transcription factor (TF) proteins bind to DNA to regulate gene expression. Normally,
accessibility to DNA is required for their function. However, in the nucleus the DNA is often …