[HTML][HTML] Integrated proteogenomic characterization of clear cell renal cell carcinoma
To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma
(ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic …
(ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic …
[HTML][HTML] The nasal methylome as a biomarker of asthma and airway inflammation in children
A Cardenas, JE Sordillo, SL Rifas-Shiman… - Nature …, 2019 - nature.com
The nasal cellular epigenome may serve as biomarker of airway disease and environmental
response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age …
response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age …
[HTML][HTML] Before and after: comparison of legacy and harmonized TCGA genomic data commons' data
We present a systematic analysis of the effects of synchronizing a large-scale, deeply
characterized, multi-omic dataset to the current human reference genome, using updated …
characterized, multi-omic dataset to the current human reference genome, using updated …
DNA methylation correlates of PTSD: Recent findings and technical challenges
There is increasing evidence that epigenetic factors play a critical role in posttraumatic
stress disorder (PTSD), by mediating the impact of environmental exposures to trauma on …
stress disorder (PTSD), by mediating the impact of environmental exposures to trauma on …
[HTML][HTML] Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms
allowing integration of genetic and environmental factors to shape cellular function. While …
allowing integration of genetic and environmental factors to shape cellular function. While …
[HTML][HTML] Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels
The human pan-tissue epigenetic clock is widely used for estimating age across the entire
lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental …
lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental …
[HTML][HTML] Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1
Background Epigenetic clocks are mathematical models that predict the biological age of an
individual using DNA methylation data and have emerged in the last few years as the most …
individual using DNA methylation data and have emerged in the last few years as the most …
IDH3α regulates one-carbon metabolism in glioblastoma
JL May, FM Kouri, LA Hurley, J Liu… - Science …, 2019 - science.org
Mutation or transcriptional up-regulation of isocitrate dehydrogenases 1 and 2 (IDH1 and
IDH2) promotes cancer progression through metabolic reprogramming and epigenetic …
IDH2) promotes cancer progression through metabolic reprogramming and epigenetic …
Integrative genomic characterization identifies molecular subtypes of lung carcinoids
SV Laddha, EM Da Silva, K Robzyk, BR Untch, H Ke… - Cancer research, 2019 - AACR
Lung carcinoids (LC) are rare and slow growing primary lung neuroendocrine tumors. We
performed targeted exome sequencing, mRNA sequencing, and DNA methylation array …
performed targeted exome sequencing, mRNA sequencing, and DNA methylation array …
Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status
HP Santos Jr, A Bhattacharya, EM Martin, K Addo… - Epigenetics, 2019 - Taylor & Francis
This study evaluated the hypothesis that prenatal maternal socioeconomic status (SES)
adversity is associated with DNA methylation in the placenta. SES adversity was defined by …
adversity is associated with DNA methylation in the placenta. SES adversity was defined by …