Myoferlin, a multifunctional protein in normal cells, has novel and key roles in various cancers
W Zhu, B Zhou, C Zhao, Z Ba, H Xu… - Journal of cellular …, 2019 - Wiley Online Library
Myoferlin, a protein of the ferlin family, has seven C2 domains and exhibits activity in some
cells, including myoblasts and endothelial cells. Recently, myoferlin was identified as a …
cells, including myoblasts and endothelial cells. Recently, myoferlin was identified as a …
Myoferlin, a membrane protein with emerging oncogenic roles
Y Dong, H Kang, H Liu, J Wang, Q Guo… - BioMed Research …, 2019 - Wiley Online Library
Myoferlin (MYOF), initially identified in muscle cells, is a member of the Ferlin family involved
in membrane fusion, membrane repair, and membrane trafficking. Dysfunction of this protein …
in membrane fusion, membrane repair, and membrane trafficking. Dysfunction of this protein …
Myoferlin contributes to the metastatic phenotype of pancreatic cancer cells by enhancing their migratory capacity through the control of oxidative phosphorylation
G Rademaker, B Costanza, S Anania, F Agirman… - Cancers, 2019 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies with an
overall survival of 5% and is the second cause of death by cancer, mainly linked to its high …
overall survival of 5% and is the second cause of death by cancer, mainly linked to its high …
Myoferlin regulates Wnt/β-catenin signaling-mediated skeletal muscle development by stabilizing dishevelled-2 against autophagy
S Han, C Cui, H He, X Shen, Y Chen, Y Wang… - International Journal of …, 2019 - mdpi.com
Myoferlin (MyoF), which is a calcium/phospholipid-binding protein expressed in cardiac and
muscle tissues, belongs to the ferlin family. While MyoF promotes myoblast differentiation …
muscle tissues, belongs to the ferlin family. While MyoF promotes myoblast differentiation …
Ferlin overview: from membrane to cancer biology
In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in
membrane processes such as fusion, recycling, endo-and exocytosis. They harbour several …
membrane processes such as fusion, recycling, endo-and exocytosis. They harbour several …
Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
Colon adenocarcinoma is the third most commonly diagnosed cancer and the second
deadliest one. Metabolic reprogramming, described as an emerging hallmark of malignant …
deadliest one. Metabolic reprogramming, described as an emerging hallmark of malignant …
[HTML][HTML] Cullin-3–dependent deregulation of ACTN1 represents a pathogenic mechanism in nemaline myopathy
Nemaline myopathy is a congenital neuromuscular disorder characterized by muscle
weakness, fiber atrophy, and presence of nemaline bodies within myofibers. However …
weakness, fiber atrophy, and presence of nemaline bodies within myofibers. However …
Structural basis for the distinct membrane binding activity of the homologous C2A domains of myoferlin and dysferlin
FM Harsini, AA Bui, AM Rice, S Chebrolu… - Journal of molecular …, 2019 - Elsevier
Dysferlin has been implicated in acute membrane repair processes, whereas myoferlin's
activity is maximal during the myoblast fusion stage of early skeletal muscle cell …
activity is maximal during the myoblast fusion stage of early skeletal muscle cell …
Truncating Variant in Myof Gene Is Associated With Limb-Girdle Type Muscular Dystrophy and Cardiomyopathy
A Kiselev, R Vaz, A Knyazeva, A Sergushichev… - Frontiers in …, 2019 - frontiersin.org
Even though genetic studies of individuals with neuromuscular diseases have uncovered
the molecular background of many cardiac disorders such as cardiomyopathies and …
the molecular background of many cardiac disorders such as cardiomyopathies and …
Methylation status and expression patterns of myomaker gene play important roles in postnatal development in the Japanese flounder (Paralichthys olivaceus)
Y Huang, S Wu, J Zhang, H Wen, M Zhang… - General and Comparative …, 2019 - Elsevier
Myomaker is a membrane protein that plays a crucial role in the fusion of myoblasts during
muscle growth. DNA methylation, a significant factor, regulates gene expression. The aim of …
muscle growth. DNA methylation, a significant factor, regulates gene expression. The aim of …