Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse
biological processes and emerged as vital players controlling tumorigenesis. Several …

For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant
splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques …

The success of targeted or immune therapies is often hampered by the emergence of
resistance and/or clinical benefit in only a subset of patients. We hypothesized that …

Oncogenic KRAS mutations are major drivers of lung adenocarcinoma (LAC), yet the direct
therapeutic targeting of KRAS has been problematic. Here, we reveal an obligate …

Background Lung cancer remains a leading cause of cancer incidence and mortality
worldwide. Although Spain contributes to global statistics related to cancer, it is difficult to …

Most cancer diagnoses rely on biomarkers detection. This could be improved if directly
conducted in suspicious cancer spots, preventing the need for biopsy. Lung cancer remains …

Mansonone G (MG), a plant-derived compound isolated from the heartwood of Mansonia
gagei, possesses a potent antitumor effect on several kinds of malignancy. However, its poor …

The epidermal growth factor receptor (EGFR) is historically the prototypical receptor tyrosine
kinase, being the first cloned and the first where the importance of ligand-induced dimer …

Background: Chemotherapy for non-small-cell lung cancer (NSCLC) still leads to
unsatisfactory clinical prognosis because of poor active targeting and tumor metastasis …

At initial diagnosis, most patients with small-cell lung cancer (SCLC) present with metastatic
disease with a high number of tumor cells (CTCs) circulating in the blood. We analyzed RNA …