In vitro three-dimensional (3D) microengineered tissue models have been the recent focus
of pathophysiological studies, particularly in the field of cardiovascular research. These …

Pompe disease is a neuromuscular disease caused by a deficiency of the lysosomal
enzyme acid alpha-glucosidase leading to lysosomal and cytoplasmic glycogen …

Cardiovascular diseases remain the leading cause of death in the developed world,
accounting for more than 30% of all deaths. In a large proportion of these patients, acute …

Based on the protein kinase A (PKA)/GSK3β interaction protein (GSKIP)/glycogen synthase
kinase 3β (GSK3β) axis, we hypothesized that these might play a role in Tau …

Infantile onset Pompe disease (IOPD) is a rare and lethal genetic disorder caused by the
deletion of the acid alpha-glucosidase (GAA) gene. This gene encodes an essential …

Background Pompe disease is a neuromuscular disease caused by a deficiency of
lysosomal acid alpha-glucosidase (GAA) which degrades glycogen, resulting in progressive …

Hypertrophic cardiomyopathy (HCM) is one of the most commonly inherited cardiac
disorders that manifests with increased ventricular wall thickening, cardiomyocyte …

Abstract Pompe disease (OMIM# 232300) is a glycogen storage disease caused by
autosomal recessive mutations of the gene encoding alpha-1, 4-glucosidase (GAA; EC 3.2 …

Infantile-onset Pompe disease (IOPD) is a life-threatening multi-organ disease caused by an
inborn defect of lysosomal acid α-glucosidase (GAA), which can degrade glycogen into …

Cardiomyopathies are disorders with primary defect of the cardiac muscle, typically
presenting in a familial context and associated with mutations in major determinants of the …