BACKGROUND The human uterine endometrium undergoes significant remodeling and
regeneration on a rapid and repeated basis, after parturition, menstruation, and in some …

If occupational tumors are excluded, cancer causes are largely unknown. Therefore, it
appeared useful to work out a theory explaining the complexity of this disease. More than …

Exosomes are naturally secreted nanovesicles that have emerged as a promising
therapeutic nanodelivery platform, due to their specific composition and biological …

Glial dysfunction is a major pathophysiological feature of mood disorders. While altered
astrocyte (AS) and oligodendrocyte-lineage (OL) functions have been associated with …

Gap junction proteins are expressed in cancer stem cells and non-stem cancer cells of many
tumors. As the morphology and assembly of gap junction channels are crucial for their …

Abstract Phosphorylation regulates connexin43 (Cx43) function from assembly/disassembly
to coupling at the plaque. Src is a tyrosine kinase known to both phosphorylate Cx43 …

Micro RNA is expected to be a novel therapeutic tool for tumors. Gap junctions facilitate the
transfer of micro RNA, which exerts biological effects on tumor cells. However, the length of …

Abstract Pannexin 3 (Panx3) is a regulator of bone formation. Panx3 forms three distinct
functional channels: hemichannels, gap junctions, and endoplasmic reticulum (ER) Ca2+ …

Emerging evidence indicates that adipose stromal cells (ASC) are recruited to enhance
cancer development. In this study, we examined the role these adipocyte progenitors play …

Autosomal dominant congenital cataract (ADCC), the most common hereditary disease, is a
major cause of eye disease in children. Due to its high genetic and clinical heterogeneity …