The genetic landscape of pituitary adenomas (PAs) is diverse and many of the identified
cases remain of unclear pathogenetic mechanism. Germline genetic defects account for a …

Pituitary adenomas are frequently occurring neoplasms that produce clinically significant
disease in 1: 1000 of the general population. The pathogenesis of pituitary tumors is a …

Background: The vast majority of pituitary tumors are benign and behave accordingly;
however, a fraction are invasive and are more aggressive, with a very small fraction being …

Pituitary neuroendocrine tumors (PitNETs) constitute approximately 15% of all brain tumors,
and most have a sporadic origin. Recent studies suggest that altered alternative splicing …

Context Genomic losses/gains are associated with cancer progression and prognosis. In
pituitary adenomas, analyses of copy number variations (CNVs) have shown that a subset of …

Context Besides GNAS gene mutations, the molecular pathogenesis of somatotroph
adenomas responsible for gigantism and acromegaly remains elusive. Objective To …

Congenital and genetic disorders cause many diseases in Arab countries due to large family
sizes and high levels of inbreeding. Saudi Arabia (SA) has the highest consanguinity rates …

Background Acromegaly is produced by excess growth hormone secreted by a pituitary
adenoma of somatotroph cells (ACRO). First-line therapy, surgery and adjuvant therapy with …

Somatic GNAS and USP8 mutations have been implicated in sporadic somatotrophinomas
and corticotrophinomas, respectively. However, no genes are known to be recurrently …

Introduction: This review explores insights provided by next-generation sequencing (NGS) of
pituitary tumors and the clinical implications. Areas covered: Although syndromic forms …