[HTML][HTML] C-terminal end of Aquaporin 0 regulates lens gap junction channel function

K Varadaraj, J Gao, RT Mathias… - … Ophthalmology & Visual …, 2019 - tvst.arvojournals.org
Purpose: We reported previously that aquaporin 0 (AQP0) modulates lens fiber cell gap
junction (GJ) channel function. The present study was conducted to find out whether the C …

Deletion of seventeen amino acids at the C-terminal end of aquaporin 0 causes distortion aberration and cataract in the lenses of AQP0ΔC/ΔC mice

K Varadaraj, S Kumari - Investigative Ophthalmology & Visual …, 2019 - iovs.arvojournals.org
Purpose: Investigate the effects of the absence of 17 amino acids at the C-terminal end of
Aquaporin 0 (AQP0) on lens transparency, focusing property, and homeostasis. Methods: A …

A predominant form of C-terminally end-cleaved AQP0 functions as an open water channel and an adhesion protein in AQP0ΔC/ΔC mouse lens

SS Kumari, K Varadaraj - Biochemical and biophysical research …, 2019 - Elsevier
The purpose of this investigation was to find out whether C-terminally end-cleaved
aquaporin 0 (AQP0), that is present predominantly in the lens mature fiber cells of the WT …

Positively charged amino acid residues in the extracellular loops A and C of lens aquaporin 0 interact with the negative charges in the plasma membrane to facilitate …

S Kumari, G Taginik, S Varadaraj, K Varadaraj - Experimental eye research, 2019 - Elsevier
This investigation was undertaken to find out whether the positive charges in the
Extracellular Loops A (ELA) and C (ELC) of Aquaporin 0 (AQP0) are involved in lens fiber …