Regulation of fibroblast growth factor 23 (FGF 23) in health and disease
L Bär, C Stournaras, F Lang, M Föller - FEBS letters, 2019 - Wiley Online Library
Fibroblast growth factor 23 (FGF 23) is mainly produced in the bone and, upon secretion,
forms a complex with a FGF receptor and coreceptor αKlotho. FGF 23 can exert several …
forms a complex with a FGF receptor and coreceptor αKlotho. FGF 23 can exert several …
[HTML][HTML] FGF23, biomarker or target?
C Rodelo-Haad, R Santamaria, JR Muñoz-Castañeda… - Toxins, 2019 - mdpi.com
Fibroblast growth factor 23 (FGF23) plays a key role in the complex network between the
bones and other organs. Initially, it was thought that FGF23 exclusively regulated phosphate …
bones and other organs. Initially, it was thought that FGF23 exclusively regulated phosphate …
[HTML][HTML] FGF23-mediated activation of local RAAS promotes cardiac hypertrophy and fibrosis
I Böckmann, J Lischka, B Richter, J Deppe… - International Journal of …, 2019 - mdpi.com
Patients with chronic kidney disease (CKD) are prone to developing cardiac hypertrophy
and fibrosis, which is associated with increased fibroblast growth factor 23 (FGF23) serum …
and fibrosis, which is associated with increased fibroblast growth factor 23 (FGF23) serum …
[HTML][HTML] The axis of local cardiac endogenous Klotho-TGF-β1-Wnt signaling mediates cardiac fibrosis in human
Q Liu, LJ Zhu, AM Waaga-Gasser, Y Ding… - Journal of Molecular and …, 2019 - Elsevier
Background Cardiovascular fibrosis is a major contributor to cardiovascular disease, the
primary cause of death in patients with chronic kidney disease (CKD). We previously …
primary cause of death in patients with chronic kidney disease (CKD). We previously …
FGF23 regulates atrial fibrosis in atrial fibrillation by mediating the STAT3 and SMAD3 pathways
Q Dong, S Li, W Wang, L Han, Z Xia… - Journal of Cellular …, 2019 - Wiley Online Library
High fibroblast growth factor 23 (FGF23) concentrations are a strong predictor of atrial
fibrillation (AF), but researchers have not clearly determined the mechanism by which …
fibrillation (AF), but researchers have not clearly determined the mechanism by which …
Chronic kidney disease and the pathophysiology of valvular heart disease
J Ternacle, N Côté, L Krapf, A Nguyen… - Canadian Journal of …, 2019 - Elsevier
Valvular heart calcification is common in patients with chronic kidney disease (CKD),
especially in those receiving hemodialysis therapy, and it is associated with poor prognosis …
especially in those receiving hemodialysis therapy, and it is associated with poor prognosis …
Cardioprotective effects of paricalcitol alone and in combination with FGF23 receptor inhibition in chronic renal failure: experimental and clinical studies
BACKGROUND In uremic animals, vitamin D receptor (VDR) agonists like paricalcitol (Pc)
attenuate cardiac hypertrophy, but this effect has not been replicated consistently in humans …
attenuate cardiac hypertrophy, but this effect has not been replicated consistently in humans …
Meta-analysis of the association between fibroblast growth factor 23 and mortality and cardiovascular events in hemodialysis patients
S Gao, J Xu, S Zhang, J Jin - Blood purification, 2019 - karger.com
Introduction: This study was conducted to ensure the correlation between fibroblast growth
factor 23 (FGF23) and death and cardiovascular events in hemodialysis patients. Methods …
factor 23 (FGF23) and death and cardiovascular events in hemodialysis patients. Methods …
[HTML][HTML] FGF23 in hemodialysis patients is associated with left ventricular hypertrophy and reduced ejection fraction
TL Nielsen, LL Plesner, PE Warming, OH Mortensen… - nefrologia, 2019 - Elsevier
Background Fibroblast growth factor 23 (FGF23) is known to cause left ventricular
hypertrophy (LVH), but controversy exists concerning its effect in dialysis. This study …
hypertrophy (LVH), but controversy exists concerning its effect in dialysis. This study …
Fibroblast growth factor 23 is associated with fractional excretion of sodium in patients with chronic kidney disease
H Xu, A Hashem, A Witasp, R Mencke… - Nephrology Dialysis …, 2019 - academic.oup.com
Background Recent studies suggest that the phosphaturic hormone fibroblast growth factor
23 (FGF23) is involved in regulation of renal sodium excretion and blood pressure. There is …
23 (FGF23) is involved in regulation of renal sodium excretion and blood pressure. There is …