Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast
cancer (TNBC) comprises around 15~ 20% of breast cancers. Conventional chemotherapy …

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context …

In this concept article, we outline a variety of new approaches that have been conceived to
address some of the remaining challenges for developing improved methods of …

We report that circACC1, a circular RNA derived from human ACC1, plays a critical role in
cellular responses to metabolic stress. CircACC1 is preferentially produced over ACC1 in …

Physical performance relies on the concerted action of myriad responses, many of which are
under circadian clock control. Little is known, however, regarding the time-dependent effect …

AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent
and AMP-independent mechanisms. The conditions under which these different …

The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched
on by increases in cellular AMP: ATP ratios, it acts to restore energy homeostasis by …

Adenosine 5′-monophosphate activated protein kinase (AMPK) is a key enzymatic protein
involved in linking the energy sensing to the metabolic manipulation. It is a serine/threonine …

Gynostemma pentaphyllum is widely used in Asia as a herbal medicine to treat type 2
diabetes, dyslipidemia, and inflammation. Here, we investigated the anti-obesity effect and …