Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity.
They integrate signals derived from tissue infection or damage and present processed …

T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive
immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLO …

Tumor-resident lymphocytes can mount a response against neoantigens expressed in
microsatellite-stable gastrointestinal (GI) cancers, and adoptive transfer of neoantigen …

Intestinal immune homeostasis is dependent upon tightly regulated and dynamic host
interactions with the commensal microbiota. Immunoglobulin A (IgA) produced by mucosal B …

Sustained T cell receptor (TCR) stimulation is required for maintaining germinal center T
follicular helper (GC-TFH) cells. Paradoxically, TCR activation induces interleukin-2 receptor …

Germinal centers (GC) have been known as key anatomic structures in humoral immunity,
where isotype switching and affinity maturation occur. As a consequence, elucidation of GC …

Traditionally, chemokine immunobiology has focused on chemotaxis and the positioning of
cells at sites of inflammation and within lymphoid organs. More recently, however, regulation …

B‐cell responses are dynamic processes that depend on multiple types of interactions. Rare
antigen‐specific B cells must encounter antigen and specialized systems are needed …

Follicular T‐helper (TFH) cells play a crucial role in three aspects of the germinal center
(GC) response. They promote GC formation, arbitrate competition among GC B cells to …

A fundamental question in immunology is how cells decide between distinct T helper,
effector or memory differentiation fates. These decisions are paramount to overcome …