Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …

Selenium is an essential dietary micronutrient. Ingested selenium is absorbed by the
intestines and transported to the liver where it is mostly metabolized to selenocysteine (Sec) …

Levothyroxine (LT4) is a form of thyroid hormone used to treat hypothyroidism. In the brain,
T4 is converted to the active form T3 by type 2 deiodinase (D2). Thus, it is intriguing that …

The E3 ligase membrane-associated ring-CH-type finger 6 (MARCH6) is a polytopic enzyme
bound to the membranes of the endoplasmic reticulum. It controls levels of several known …

Cholesterol accumulation is a hallmark of prostate cancer (PCa) enabled by the
upregulation of its synthesis, which presents a potential therapeutic target. This pathway is …

Treatment of hypothyroidism involves the endogenous conversion of thyroxine (T4) to 3, 5,
3′-triiodothyronine (T3) and may not be optimal in some cases when based on T4 alone. In …

Lange ging man davon aus, dass die Physiologie der Thyroidhormone weitestgehend
erforscht ist und nahm an, dass sämtliche Thyroidhormon-Wirkungen auf einer Bildung von …