Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants

E Jacqz-Aigrain, S Leroux, AH Thomson… - Journal of …, 2019 - academic.oup.com
Objectives In the absence of consensus, the present meta-analysis was performed to
determine an optimal dosing regimen of vancomycin for neonates. Methods A 'meta …

[HTML][HTML] Vancomycin pharmacokinetics throughout life: results from a pooled population analysis and evaluation of current dosing recommendations

PJ Colin, K Allegaert, AH Thomson, DJ Touw… - Clinical …, 2019 - Springer
Abstract Background and Objectives Uncertainty exists regarding the optimal dosing
regimen for vancomycin in different patient populations, leading to a plethora of subgroup …

External evaluation of population pharmacokinetic models of vancomycin in large cohorts of intensive care unit patients

T Guo, RM van Hest, LF Roggeveen… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Dosing of vancomycin is often guided by therapeutic drug monitoring and population
pharmacokinetic models in the intensive care unit (ICU). The validity of these models is …

Revising pediatric vancomycin dosing accounting for nephrotoxicity in a pharmacokinetic-pharmacodynamic model

F Kloprogge, LF Hill, J Booth, N Klein… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
This study aimed to suggest an initial pediatric vancomycin dose regimen through
population pharmacokinetic-pharmacodynamic modeling. A population pharmacokinetic …

Population pharmacokinetics of vancomycin in the pediatric cardiac surgical population

BS Moffett, K Resendiz, J Morris… - The Journal of …, 2019 - meridian.allenpress.com
OBJECTIVE Vancomycin is often used in the pediatric cardiac surgical population, but few
pharmacokinetic data are available to guide dosing. METHODS A retrospective, population …

The effectiveness of a vancomycin dosing guideline in the neonatal intensive care unit for achieving goal therapeutic trough concentrations

AM Reilly, MX Ding, JE Rower… - The Journal of Clinical …, 2019 - Wiley Online Library
Concern for bacterial resistance and treatment failure with vancomycin trough
concentrations< 10 μg/mL have led guidelines to increase goal concentrations. There is a …

Population pharmacokinetics of oxcarbazepine active metabolite in Chinese paediatric epilepsy patients and its application in individualised dosage regimens

W Lin, X Li, Z Jiao, J Zhang, X Rao, D Zeng… - European Journal of …, 2019 - Springer
Purpose Oxcarbazepine (OXC) is an antiepileptic drug metabolised to active 10-
monohydroxy derivative (MHD) following oral administration. There are no MHD population …

Pharmacokinetics of enrofloxacin and danofloxacin in premature calves

O Corum, F Altan, R Yildiz, M Ider… - Journal of veterinary …, 2019 - Wiley Online Library
The aim of this study was to determine the pharmacokinetics/pharmacodynamics of
enrofloxacin (ENR) and danofloxacin (DNX) following intravenous (IV) and intramuscular …

Actual body weight-based vancomycin dosing in neonates

P Pokorná, M Šíma, O Černá, K Allegaert… - Journal of …, 2019 - Taylor & Francis
This study aimed to explore vancomycin pharmacokinetics and its covariates in critically ill
neonates and to propose an easy applicable dosing nomogram for initial treatment …

Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves

O Corum, R Yildiz, M Ider, F Altan… - Journal of veterinary …, 2019 - Wiley Online Library
The aim of this study was to evaluate the pharmacokinetics and bioavailability of cefquinome
(CFQ) and ceftriaxone (CTX) following intravenous (IV) and intramuscular (IM) …