Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants
E Jacqz-Aigrain, S Leroux, AH Thomson… - Journal of …, 2019 - academic.oup.com
Objectives In the absence of consensus, the present meta-analysis was performed to
determine an optimal dosing regimen of vancomycin for neonates. Methods A 'meta …
determine an optimal dosing regimen of vancomycin for neonates. Methods A 'meta …
[HTML][HTML] Vancomycin pharmacokinetics throughout life: results from a pooled population analysis and evaluation of current dosing recommendations
PJ Colin, K Allegaert, AH Thomson, DJ Touw… - Clinical …, 2019 - Springer
Abstract Background and Objectives Uncertainty exists regarding the optimal dosing
regimen for vancomycin in different patient populations, leading to a plethora of subgroup …
regimen for vancomycin in different patient populations, leading to a plethora of subgroup …
External evaluation of population pharmacokinetic models of vancomycin in large cohorts of intensive care unit patients
T Guo, RM van Hest, LF Roggeveen… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Dosing of vancomycin is often guided by therapeutic drug monitoring and population
pharmacokinetic models in the intensive care unit (ICU). The validity of these models is …
pharmacokinetic models in the intensive care unit (ICU). The validity of these models is …
Revising pediatric vancomycin dosing accounting for nephrotoxicity in a pharmacokinetic-pharmacodynamic model
F Kloprogge, LF Hill, J Booth, N Klein… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
This study aimed to suggest an initial pediatric vancomycin dose regimen through
population pharmacokinetic-pharmacodynamic modeling. A population pharmacokinetic …
population pharmacokinetic-pharmacodynamic modeling. A population pharmacokinetic …
Population pharmacokinetics of vancomycin in the pediatric cardiac surgical population
BS Moffett, K Resendiz, J Morris… - The Journal of …, 2019 - meridian.allenpress.com
OBJECTIVE Vancomycin is often used in the pediatric cardiac surgical population, but few
pharmacokinetic data are available to guide dosing. METHODS A retrospective, population …
pharmacokinetic data are available to guide dosing. METHODS A retrospective, population …
The effectiveness of a vancomycin dosing guideline in the neonatal intensive care unit for achieving goal therapeutic trough concentrations
AM Reilly, MX Ding, JE Rower… - The Journal of Clinical …, 2019 - Wiley Online Library
Concern for bacterial resistance and treatment failure with vancomycin trough
concentrations< 10 μg/mL have led guidelines to increase goal concentrations. There is a …
concentrations< 10 μg/mL have led guidelines to increase goal concentrations. There is a …
Population pharmacokinetics of oxcarbazepine active metabolite in Chinese paediatric epilepsy patients and its application in individualised dosage regimens
W Lin, X Li, Z Jiao, J Zhang, X Rao, D Zeng… - European Journal of …, 2019 - Springer
Purpose Oxcarbazepine (OXC) is an antiepileptic drug metabolised to active 10-
monohydroxy derivative (MHD) following oral administration. There are no MHD population …
monohydroxy derivative (MHD) following oral administration. There are no MHD population …
Pharmacokinetics of enrofloxacin and danofloxacin in premature calves
The aim of this study was to determine the pharmacokinetics/pharmacodynamics of
enrofloxacin (ENR) and danofloxacin (DNX) following intravenous (IV) and intramuscular …
enrofloxacin (ENR) and danofloxacin (DNX) following intravenous (IV) and intramuscular …
Actual body weight-based vancomycin dosing in neonates
P Pokorná, M Šíma, O Černá, K Allegaert… - Journal of …, 2019 - Taylor & Francis
This study aimed to explore vancomycin pharmacokinetics and its covariates in critically ill
neonates and to propose an easy applicable dosing nomogram for initial treatment …
neonates and to propose an easy applicable dosing nomogram for initial treatment …
Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves
The aim of this study was to evaluate the pharmacokinetics and bioavailability of cefquinome
(CFQ) and ceftriaxone (CTX) following intravenous (IV) and intramuscular (IM) …
(CFQ) and ceftriaxone (CTX) following intravenous (IV) and intramuscular (IM) …