Nanoemulsions in CNS drug delivery: recent developments, impacts and challenges

Z Karami, MRS Zanjani, M Hamidi - Drug discovery today, 2019 - Elsevier
Highlights•Nanoemulsions are among promising nanocarriers for various biomedical
applications.•Biocompatibility and simplicity are the most important advantages of …

[HTML][HTML] The extracellular matrix and biocompatible materials in glioblastoma treatment

A Belousov, S Titov, N Shved, M Garbuz… - … in bioengineering and …, 2019 - frontiersin.org
During cancer genesis, the extracellular matrix (ECM) in the human brain undergoes
important transformations, starting to resemble embryonic brain cell milieu with a much …

Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol

L Meng, X Chu, H Xing, X Liu, X Xin, L Chen… - International journal of …, 2019 - Elsevier
Glioblastoma is a grade IV malignant glioma with high recurrence and metastasis and faces
a therapeutic obstacle that the blood-brain barrier (BBB) severely hinders the brain entry …

Tumor targeting by peptide-decorated gold nanoparticles

B Albertini, V Mathieu, N Iraci… - Molecular …, 2019 - ACS Publications
Cancer remains one of the most important challenges in biomedical sciences.
Chemotherapeutic agents are very potent molecules that exhibit a significant level of toxicity …

[HTML][HTML] Magnetic composite biomaterials for neural regeneration

JL Funnell, B Balouch, RJ Gilbert - Frontiers in Bioengineering and …, 2019 - frontiersin.org
Nervous system damage caused by physical trauma or degenerative diseases can result in
loss of sensory and motor function for patients. Biomaterial interventions have shown …

[HTML][HTML] The potential of magnetic nanoparticles for diagnosis and treatment of cancer based on body magnetic field and organ-on-the-chip

AA Alavijeh, M Barati, M Barati… - Advanced …, 2019 - ncbi.nlm.nih.gov
Cancer is an abnormal cell growth which tends to proliferate in an uncontrolled way and, in
some cases, leads to metastasis. If cancer is left untreated, it can immediately cause death …

Enhanced intraliposomal metallic nanoparticle payload capacity using microfluidic-assisted self-assembly

ZS Al-Ahmady, R Donno, A Gennari, E Prestat… - Langmuir, 2019 - ACS Publications
Hybrids composed of liposomes (L) and metallic nanoparticles (NPs) hold great potential for
imaging and drug delivery purposes. However, the efficient incorporation of metallic NPs …

Recent progress in blood-brain barrier transportation research

G Li, K Shao, CS Umeshappa - Brain targeted drug delivery system, 2019 - Elsevier
Achieving high bioavailability and enhancing therapeutic effect in the brain are the major
challenges for the development of central nervous systems (CNS)-active therapeutics …

Liposomal prodigiosin and plasmid encoding serial GCA nucleotides reduce inflammation in microglial and astrocyte cells by ATM/ATR signaling

M Rashidi, A Jebali - Journal of neuroimmunology, 2019 - Elsevier
The aim of this study was to use liposomal structure consisting prodigiosin and plasmid
encoding serial GCA nucleotides (LP/pSGCAN) to reduce inflammation in microglial cells …

Brain Diseases: An Introduction and the Need for Novel Drug-Delivery Approaches

SS Mamada, M Salampe, R Sharma… - … for Brain Drug Delivery - taylorfrancis.com
There have been many challenges encountered over time in the attempt to cure illnesses
that affect the brain. One major hindrance is related to the existence of the blood–brain …