N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the
effects of a high-fat diet (HFD) on the development of insulin resistance. Here, we show that …

Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In
addition, it is a key regulator of apoptosis. Cytc has multiple other functions including ROS …

Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Lysine acetylation is a reversible posttranslational modification that occurs at thousands of
sites on human proteins. However, the stoichiometry of acetylation remains poorly …

Lysine post-translational modifications (PTMs) play a crucial role in regulating diverse
functions and biological processes of proteins. However, because of the large volumes of …

While nuclear lamina abnormalities are hallmarks of human diseases, their interplay with
epigenetic regulators and precise epigenetic landscape remain poorly understood. Here, we …

Class III histone deacetylases (HDACs) belong to the proteasome family, comprising seven
family members identified in mammalian cells, identified Sirt1–Sirt7. As an important …