Targeting HIF-1α signaling pathway for gastric cancer treatment

H Li, Y Jia, Y Wang - Die Pharmazie-An International Journal of …, 2019 - ingentaconnect.com
Gastric cancer is a common malignancy with high mortality and limited therapeutic options.
Hypoxia inducible factor-1 α (HIF-1α) is the key responser adapted to tumor hypoxia. Under …

Energetic adaptations: Metabolic control of endocytic membrane traffic

S Rahmani, MS Defferrari, WW Wakarchuk… - Traffic, 2019 - Wiley Online Library
Endocytic membrane traffic controls the access of myriad cell surface proteins to the
extracellular milieu, and thus gates nutrient uptake, ion homeostasis, signaling, adhesion …

[HTML][HTML] Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma

N Sethi, O Kikuchi, J McFarland, Y Zhang, M Chung… - JCI insight, 2019 - ncbi.nlm.nih.gov
Despite the propensity for gastric and esophageal adenocarcinomas to select for recurrent
missense mutations in TP53, the precise functional consequence of these mutations …

Correlation and expression analysis of hypoxia‑inducible factor 1α, glucose transporter 1 and lactate dehydrogenase 5 in human gastric cancer

LS Hao, Q Liu, C Tian, DX Zhang… - Oncology …, 2019 - spandidos-publications.com
The development and identification of novel potential targeting sites for intervention therapy
are essential in the search for improved treatment methods for gastric cancer (GC) …

Linc‑pint overexpression inhibits the growth of gastric tumors by downregulating HIF‑1α

L Hong, J Wang, H Wang, S Wei… - Molecular …, 2019 - spandidos-publications.com
Long intergenic non‑protein coding RNA, p53 induced transcript (Linc‑pint) has been
reported to be downregulated in various cancer cell lines; however, its expression profile …

[PDF][PDF] Interactions between hypoxia-inducible factor-1α and other molecules in cancer: a literature review

Y Sun, Q Hao, T Jing - Int J Clin Exp Med, 2019 - e-century.us
Hypoxia is a critical characteristic for malignant tumor progression. Transcription factor
hypoxia-inducible factor-1α (HIF-1α) plays a fundamental role, assisting with adaption to a …

[PDF][PDF] HIF-1α shRNAs delivered by ultrasound-targeted cationic microbubble inhibit proliferation, migration, and invasion of ovarian cancer cells

X Zhang, Z Chen, Q Qian, L Liu, E Xue, J Yang… - Int J Clin Exp …, 2019 - e-century.us
Development of effective and safe treatment for ovarian cancer is urgent. In this study, a
novel cationic microbubble was fabricated using the sonication method. The resulting …