Structure and function of IP3 receptors
Inositol 1, 4, 5-trisphosphate receptors (IP3Rs), by releasing Ca2+ from the endoplasmic
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
[HTML][HTML] IP3 receptors and Ca2+ entry
Abstract Inositol 1, 4, 5-trisphosphate receptors (IP 3 R) are the most widely expressed
intracellular Ca 2+ release channels. Their activation by IP 3 and Ca 2+ allows Ca 2+ to …
intracellular Ca 2+ release channels. Their activation by IP 3 and Ca 2+ allows Ca 2+ to …
Redox regulation of ER and mitochondrial Ca2+ signaling in cell survival and death
SK Joseph, DM Booth, MP Young, G Hajnóczky - Cell Calcium, 2019 - Elsevier
Physiological signaling by reactive oxygen species (ROS) and their pathophysiological role
in cell death are well recognized. This review focuses on two ROS targets that are key to …
in cell death are well recognized. This review focuses on two ROS targets that are key to …
IP3 receptors and store-operated Ca2+ entry: a license to fill
Highlights•Structural studies are revealing how IP 3 and Ca 2+ together cause the IP 3 R to
open.•Clusters of immobile IP 3 Rs adjacent to the plasma membrane are licensed to …
open.•Clusters of immobile IP 3 Rs adjacent to the plasma membrane are licensed to …
GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C
P Atakpa, LM van Marrewijk… - Journal of cell …, 2019 - journals.biologists.com
The dipeptide glycyl-l-phenylalanine 2-naphthylamide (GPN) is widely used to perturb
lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to …
lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to …
Coding and decoding of oscillatory Ca2+ signals
About 30 years after their first observation, Ca 2+ oscillations are now recognised as a
universal mechanism of signal transduction. These oscillations are driven by periodic cycles …
universal mechanism of signal transduction. These oscillations are driven by periodic cycles …
Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output
H Ivanova, LE Wagner, A Tanimura… - Cellular and Molecular …, 2019 - Springer
Bcl-2 proteins have emerged as critical regulators of intracellular Ca 2+ dynamics by directly
targeting and inhibiting the IP 3 receptor (IP 3 R), a major intracellular Ca 2+-release …
targeting and inhibiting the IP 3 receptor (IP 3 R), a major intracellular Ca 2+-release …
Spatial-temporal patterning of Ca2+ signals by the subcellular distribution of IP3 and IP3 receptors
The patterning of cytosolic Ca 2+ signals in space and time underlies their ubiquitous ability
to specifically regulate numerous cellular processes. Signals mediated by liberation of Ca …
to specifically regulate numerous cellular processes. Signals mediated by liberation of Ca …
ER Ca2+ release and store-operated Ca2+ entry–partners in crime or independent actors in oncogenic transformation?
C Pierro, F Sneyers, G Bultynck, HL Roderick - Cell Calcium, 2019 - Elsevier
Ca 2+ is a pleiotropic messenger that controls life and death decisions from fertilisation until
death. Cellular Ca 2+ handling mechanisms show plasticity and are remodelled throughout …
death. Cellular Ca 2+ handling mechanisms show plasticity and are remodelled throughout …
IP3 receptors – lessons from analyses ex cellula
ABSTRACT Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) are widely expressed
intracellular channels that release Ca2+ from the endoplasmic reticulum (ER). We review …
intracellular channels that release Ca2+ from the endoplasmic reticulum (ER). We review …