uORF-mediated translational control: recently elucidated mechanisms and implications in cancer
HH Chen, WY Tarn - RNA biology, 2019 - Taylor & Francis
Protein synthesis is tightly regulated, and its dysregulation can contribute to the pathology of
various diseases, including cancer. Increased or selective translation of mRNAs can …
various diseases, including cancer. Increased or selective translation of mRNAs can …
[HTML][HTML] ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
Understanding the intrinsic mediators that render CD8+ T cells dysfunctional in the tumor
microenvironment is a requirement to develop more effective cancer immunotherapies …
microenvironment is a requirement to develop more effective cancer immunotherapies …
Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma
I Buondonno, E Gazzano, E Tavanti, K Chegaev… - Cellular and Molecular …, 2019 - Springer
Doxorubicin is one of the most effective drugs for the first-line treatment of high-grade
osteosarcoma. Several studies have demonstrated that the major cause for doxorubicin …
osteosarcoma. Several studies have demonstrated that the major cause for doxorubicin …
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts
E Gazzano, I Buondonno, A Marengo, B Rolando… - Cancer Letters, 2019 - Elsevier
Doxorubicin (dox) is one of the first-line drug in osteosarcoma treatment but its effectiveness
is limited by the efflux pump P-glycoprotein (Pgp) and by the onset of cardiotoxicity. We …
is limited by the efflux pump P-glycoprotein (Pgp) and by the onset of cardiotoxicity. We …
Role of JNK and CHOP in the pathogenesis of liver disease due to Z alpha-1 antitrypsin
S Attanasio - 2019 - air.unimi.it
Alpha-1 antitrypsin (AAT) deficiency is a genetic disease that can affect both the lung and
the liver. The vast majority of patients harbor a mutation in the SERPINA1 gene resulting in a …
the liver. The vast majority of patients harbor a mutation in the SERPINA1 gene resulting in a …