Clostridioides difficile is an important nosocomial pathogen increasingly observed in the
community and in different non-human reservoirs. The epidemiology and transmissibility of …

Whole-genome sequences are now available for all the clinically important clostridia and
many of the lesser or opportunistically pathogenic clostridia. The complex clade structures of …

Background Whole genome sequencing (WGS) studies can enhance our understanding of
the role of patients with asymptomatic Clostridium difficile colonization in transmission …

To trace the routes and frequencies of transmission of Clostridioides difficile in a tertiary-care
hospital in Madrid (Spain), we sequenced the genomes from all C. difficile isolates collected …

Background Clostridium difficile infection (CDI) is known as one of the most important
causes of nosocomial infections. The main objective of this study was to evaluate the …

Background Microbial whole genome sequencing (WGS) has many advantages over
standard microbiological methods. However, it is not yet widely implemented in routine …

Clostridium difficile, the most common cause of hospital-associated diarrhoea in developed
countries, presents major public health challenges. The high clinical and economic burden …

Abstract Background The epidemic Clostridioides difficil e ribotype 027 strain resulted from
the dissemination of 2 separate fluoroquinolone-resistant lineages: FQR1 and FQR2. Both …

Abstract Objectives Rates of Clostridioides (Clostridium) difficile infection (CDI) are higher in
North Wales than elsewhere in the UK. We used WGS to investigate if this is due to …

Whole-genome sequencing is increasingly adopted in clinical settings to identify pathogen
transmissions, though largely as a retrospective tool. Prospective monitoring, in which …