DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …

The measurement of DNA adducts, the covalent modifications of DNA upon the exposure to
the environmental and dietary genotoxicants and endogenously produced electrophiles …

Long-term exposures to environmental toxicants are causative factors for human health
effects. DNA damages are of great interest in that they can serve as the potential biomarkers …

Frequent exposure to chemicals in the environment, diet, and endogenous electrophiles
leads to chemical modification of DNA and the formation of DNA adducts. Some DNA …

Characterization of the chemistry, structure, formation, and metabolism of DNA adducts has
been one of the most significant contributions to the field of chemical toxicology. This work …

Quantitative measurement of DNA adducts in carcinogen-exposed cells provides the
information about the frequency of formation and the rate of removal of DNA lesions in vivo …

Prostate cancer (PC) is the most commonly diagnosed non-cutaneous cancer and the
second leading cause of cancer-related to death in men. The major risk factors for PC are …

Epidemiology and laboratory studies support the conclusion that air pollution is carcinogenic
to humans. Chemically specific biomarkers are useful for determining human exposure to …

(Methylnitrosamino)-l-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN), two
tobacco specific nitrosamine carcinogens, can form adducts with DNA and proteins via …

2-Amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline (MeIQx), one of the most abundant
heterocyclic aromatic amines (HAAs) found in the human diet, is primarily produced during …