The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

The past decades have witnessed rapid development in organic synthesis via catalysis,
particularly the reactions through C–H bond functionalization. Transition metals such as Pd …

The tetrahydro-β-carboline (THBC) nucleus is a predominant feature of a vast array of
naturally occurring alkaloids. Most of these alkaloids have been found to exhibit significant …

Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone
scaffold was designed by scaffold hopping. Structure–activity relationship studies led to the …

Natural product evodiamine and its derivatives represent a promising class of multi-target
antitumor agents. However, the clinical development of these compounds has been …

Topoisomerases are DNA processing enzymes that relieve supercoiling (torsional strain) in
DNA, are necessary for normal cellular division, and act by nicking (and then religating) …

Efficient access to evodiamine and its analogues is presented via Lewis acid catalysis. In
this reaction, three chemical bonds and two heterocyclic-fused rings are constructed in one …

Silver-mediated intramolecular α-C (sp3)–H bond functionalization of the methylthio group
has been established in the presence of Selectfluor as an additive. This novel strategy …

Nitrogen mustards, a family of DNA alkylating agents, marked the start of cancer
pharmacotherapy. While traditionally characterized by their dose-limiting toxic effects …

We live in a world with complex diseases such as cancer which cannot be cured with one-
compound one-target based therapeutic paradigm. This could be due to the involvement of …