Adoptive T cell transfer therapy (ACT) using tumor infiltrating lymphocytes or lymphocytes
redirected with antigen receptors (CAR or TCR) has revolutionized the field of cancer …

Chimeric antigen receptors (CARs) are synthetic receptors that target and reprogram T cells
to acquire augmented antitumor properties. CD19-specific CARs that comprise CD28 and …

Summary CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal
autoimmunity. Tregs undertake differentiation processes and acquire diverse functional …

Tcf1 and Lef1 have versatile functions in regulating T cell development and differentiation,
but intrinsic requirements for these factors in regulatory T (T reg) cells remain to be …

The long-term persistence of viral antigens drives virus-specific CD8 T cell exhaustion
during chronic viral infection. Yet exhausted, CD8 T cells are still endowed with certain …

The differentiation of memory CD8+ T cells is critical to the long-term cellular immunity. The
transcription factor BCL6 has been reportedly important for the generation and maintenance …

Autophagy plays a critical role in the maintenance of immunological memory. However, the
molecular mechanisms involved in autophagy-regulated effector memory formation in CD8+ …

Background B-cell receptor (BCR) signaling, combined with CD19 and CD21 signals,
imparts specific control of B-cell responses. Dedicator of cytokinesis protein 2 (DOCK2) is …

Cytotoxic CD8+ T cells (CTLs) are crucial for controlling intracellular pathogens as well as
cancer. However, how to promote the cytotoxic activity of CTL cells in vitro and in vivo …

T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) proteins from the High Mobility
Group (HMG) box family act as the main downstream effectors of the Wnt signaling pathway …