[HTML][HTML] Humanising the mouse genome piece by piece
F Zhu, RR Nair, EMC Fisher, TJ Cunningham - Nature communications, 2019 - nature.com
To better understand human health and disease, researchers create a wide variety of mouse
models that carry human DNA. With recent advances in genome engineering, the targeted …
models that carry human DNA. With recent advances in genome engineering, the targeted …
Metalloproteinases and their tissue inhibitors in Alzheimer's disease and other neurodegenerative disorders
S Rivera, L García-González, M Khrestchatisky… - Cellular and Molecular …, 2019 - Springer
As life expectancy increases worldwide, age-related neurodegenerative diseases will
increase in parallel. The lack of effective treatment strategies may soon lead to an …
increase in parallel. The lack of effective treatment strategies may soon lead to an …
[HTML][HTML] Cell-autonomous and non-cell-autonomous pathogenic mechanisms in Huntington's disease: insights from in vitro and in vivo models
J Creus-Muncunill, ME Ehrlich - Neurotherapeutics, 2019 - Elsevier
Huntington's disease (HD) is an autosomal dominant disorder caused by an expansion in
the trinucleotide CAG repeat in exon-1 in the huntingtin gene, located on chromosome 4 …
the trinucleotide CAG repeat in exon-1 in the huntingtin gene, located on chromosome 4 …
Dysfunctional striatal dopamine signaling in Huntington's disease
ET Koch, LA Raymond - Journal of neuroscience research, 2019 - Wiley Online Library
Dopamine signaling in the striatum is critical for a variety of behaviors including movement,
behavioral flexibility, response to reward and many forms of learning. Alterations to …
behavioral flexibility, response to reward and many forms of learning. Alterations to …
[图书][B] Investigating the Dysregulation and Therapeutic Potential of Neuroprotective Stress Response Proteins in Huntington's Disease
JM Rieders - 2019 - search.proquest.com
Huntington's disease (HD) is a fatal, genetic neurodegenerative disease that shares many
features with other common neurological disorders, including early synapse loss. In both …
features with other common neurological disorders, including early synapse loss. In both …