Neural crest cells (NCCs) are a multipotent and migratory cell population in the developing
embryo that contribute to the formation of a wide range of tissues. Defects in the …

Objective Chronic megacolon is rarely encountered in clinical practice beyond infancy or
early childhood. Most cases are sporadic, and some are familial megacolon and present …

Although abnormal nuclear structure is an important criterion for cancer diagnostics,
remarkably little is known about its relationship to tumor development. Here we report that …

Hirschsprung's disease is a rare cause of neonatal intestinal obstruction due to anomalies of
the enteric nervous system (ENS). Single cases documented in Europe go back to the …

Enteric neuropathies, such as Hirschsprung disease (HSCR), comprise a number of severe
diseases of the enteric nervous system (ENS) of the gastrointestinal (GI) tract with, as yet, no …

Interstitial Cells originate from mesenchymal embryonic layer communicate with smooth
muscle cells in many organs and provide important regulatory functions. Two different …

Overall outcome of Hirschsprung disease (HSCR) remain inadequate, and the treatment
options for severe forms are limited to palliative interventions. Advances in molecular …

Surgical options using various techniques of pull-through surgery have been performed in
clinical practice as a consensus therapy for years, whereas the pathogenesis of …

The regeneration of craniofacial tissues presents a unique challenge due to their complex
structure, multiple embryonic origins and distinct molecular mechanisms of development …