Complex multicellular organisms, such as mammals, express two complete sets of
chromosomes per nucleus, combining the genetic material of both parents. However …

Imprinted genes display parent-of-origin-specific expression with this epigenetic system of
regulation found exclusively in therian mammals. Historically, defined imprinted gene …

Exome-sequencing studies have generally been underpowered to identify deleterious
alleles with a large effect on complex traits as such alleles are mostly rare. Because the …

Delta like non-canonical Notch ligand 1 (Dlk1) is an imprinted gene, mainly known for its
involvement in adipogenesis, although it has been associated with many other stem …

Pubertal timing in humans is determined by complex interactions including hormonal,
metabolic, environmental, ethnic, and genetic factors. Central precocious puberty (CPP) is …

In mammals successful rearing imposes a cost on later reproductive fitness specifically on
the mother creating the potential for parental conflict. Loss of function of three imprinted …

Genomic imprinting is a process that causes genes to be expressed according to their
parental origin. Imprinting appears to have evolved gradually in two of the three mammalian …

Parental care is found widely across animal taxa and is manifest in a range of behaviours
from basic provisioning in cockroaches to highly complex behaviours seen in mammals. The …

Intrauterine growth restriction (IUGR) is a serious clinical problem affecting about 10% of all
pregnancies, and even up to 15% of all monochorionic twin pregnancies. This disorder is …

Objective GH excess in acromegaly leads to lower fat mass and insulin resistance; both
reverse following pituitary surgery. Soluble delta like-1 homolog (sDlk1) inhibits adipocyte …