Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …

One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that
include the methionine and folate cycles that are central to cellular function, providing 1C …

A main challenge in nutritional studies is the valid and reliable assessment of food intake, as
well as its effects on the body. Generally, food intake measurement is based on self-reported …

Fetal metabolic programming caused by the adverse intrauterine environment can induce
metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal …

The type 2 diabetes epidemic and one of its predisposing factors, obesity, are major
influences on global health and economic burden. It is accepted that genetics and the …

DNA methylation is an epigenetic mark involved in regulating genome function and is critical
for normal development in mammals. It has been observed that the developmental …

Maternal nutrition plays a decisive role in developmental programming of many non-
communicable diseases (NCDs). A variety of nutritional insults during gestation can cause …

Background DNA methylation is thought to be an important determinant of human
phenotypic variation, but its inherent cell type specificity has impeded progress on this …

Living organisms are constantly exposed to wide ranges of environmental cues. They react
to these cues by undergoing a battery of phenotypic responses, such as by altering their …

Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA
methylation may modulate POMC expression and provide a biological link between early life …