Applications of guanine quartets in nanotechnology and chemical biology
L Stefan, D Monchaud - Nature Reviews Chemistry, 2019 - nature.com
Guanine and related nucleobases such as guanosine, deoxyguanosine and isoguanosine
are notable molecular tools for designing functional supramolecular assemblies. This …
are notable molecular tools for designing functional supramolecular assemblies. This …
G-quadruplex-based fluorescent turn-on ligands and aptamers: from development to applications
Guanine (G)-quadruplexes (G4s) are unique nucleic acid structures that are formed by
stacked G-tetrads in G-rich DNA or RNA sequences. G4s have been reported to play …
stacked G-tetrads in G-rich DNA or RNA sequences. G4s have been reported to play …
Lighting up the native viral RNA genome with a fluorogenic probe for the live-cell visualization of virus infection
X Luo, B Xue, G Feng, J Zhang, B Lin… - Journal of the …, 2019 - ACS Publications
RNA viruses represent a major global health threat, and the visualization of their RNA
genome in infected cells is essential for virological research and clinical diagnosis. Due to …
genome in infected cells is essential for virological research and clinical diagnosis. Due to …
Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe
Q Zhai, C Gao, J Ding, Y Zhang, B Islam… - Nucleic Acids …, 2019 - academic.oup.com
Nucleic acid mimics of fluorescent proteins can be valuable tools to locate and image
functional biomolecules in cells. Stacking between the internal G-quartet, formed in the …
functional biomolecules in cells. Stacking between the internal G-quartet, formed in the …
Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives
S Pelliccia, J Amato, D Capasso… - Journal of Medicinal …, 2019 - ACS Publications
In the search for new drug-like selective G-quadruplex binders, a bioinspired design focused
on the use of nucleobases as synthons in a multicomponent reaction was herein proved to …
on the use of nucleobases as synthons in a multicomponent reaction was herein proved to …
Development of a Smart Fluorescent Sensor That Specifically Recognizes the c-MYC G-Quadruplex
MH Hu, J Zhou, WH Luo, SB Chen, ZS Huang… - Analytical …, 2019 - ACS Publications
The specific sensing of an exact G-quadruplex structure by small molecules has never been
reported. A fluorescent sensor based on the photoinduced electron transfer (PeT) …
reported. A fluorescent sensor based on the photoinduced electron transfer (PeT) …
The application of click chemistry for targeting quadruplex nucleic acids
The Cu (I)-catalyzed azide and alkyne 1, 3-dipolar cycloaddition (CuAAC), commonly known
as the “click reaction”, has emerged as a powerful and versatile synthetic tool that finds a …
as the “click reaction”, has emerged as a powerful and versatile synthetic tool that finds a …
Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid
The variety and complexity of DNA-based structures make them attractive candidates for
nanotechnology, yet insufficient stability and mechanical rigidity, compared to polyamide …
nanotechnology, yet insufficient stability and mechanical rigidity, compared to polyamide …
Spiropyran in Situ Switching: A Real-Time Fluorescence Strategy for Tracking DNA G-Quadruplexes in Live Cells
J Li, X Yin, B Li, X Li, Y Pan, J Li, Y Guo - Analytical chemistry, 2019 - ACS Publications
DNA G-quadruplexes (G4s) in vivo have been linked to cancer and other diseases such as
neurological disorders. Nondestructive fast detection of endogenous DNA G4s can provide …
neurological disorders. Nondestructive fast detection of endogenous DNA G4s can provide …
Guidelines for the assembly of hydrogen-bonded macrocycles
F Aparicio, MJ Mayoral, C Montoro-García… - Chemical …, 2019 - pubs.rsc.org
The formation of well-defined, discrete self-assembled architectures relies on the interplay
between non-covalent interactions and cooperative phenomena. In particular, chelate or …
between non-covalent interactions and cooperative phenomena. In particular, chelate or …