The global burden of chronic kidney disease will increase during the next century. As NFκB,
first described more than 30 years ago, plays a major role in immune and non-immune …

Cancer stem cells (CSCs) account for tumor initiation, invasiveness, metastasis, and
recurrence in a broad range of human cancers. Although being a key player in cancer …

Multiple myeloma, which ranks as the second most common hematological malignancy, is
known for its great genetic heterogeneity. One pathway, however, stands out in this diverse …

The NF-κB family of dimeric transcription factors regulates transcription by selectively
binding to DNA response elements present within promoters or enhancers of target genes …

Obesity is a major contributor to the development of steatohepatitis and fibrosis from
nonalcoholic fatty liver disease (NAFLD). Hypoxia aggravates progression of NAFLD. In …

Platelets are megakaryocyte-derived fragments lacking nuclei and prepped to maintain
primary hemostasis by initiating blood clots on injured vascular endothelia. Pathologically …

Regulation of Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)/Rel
transcription factors (TFs) is extremely cell-type-specific owing to their ability to act …

Non-canonical IκB kinases (IKKs) TBK1 and IKKε have essential roles as regulators of
innate immunity and cancer. Recent work has also implicated these kinases in distinctively …

NF-κB, a family of transcription factors regulating diverse biological processes including
immune responses, is activated by canonical and noncanonical pathways based on …

The innate immunity has evolved during millions of years, and thus, equivalent or
comparable components are found in most vertebrates, invertebrates, and even plants. It …