Pancreatic cystic neoplasms (PCN) are a heterogeneous group of pancreatic cysts that
include intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, serous cystic …

In the previous decade, comprehensive genomic analyses have yielded important insights
about the genetic alterations that underlie pancreatic tumorigenesis. Whole-exome and …

Objectives Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cysts that can
progress to invasive pancreatic cancer. Associations between oncogenesis and oral …

Background & Aims Intraductal papillary mucinous neoplasms (IPMNs) are regarded as
precursors of pancreatic ductal adenocarcinomas (PDAs), but little is known about the …

Background & Aims Intraductal papillary mucinous neoplasms (IPMNs) are lesions that can
progress to invasive pancreatic cancer and constitute an important system for studies of …

Cancer evolves through a multistep process that occurs by the temporal accumulation of
genetic mutations. Tumor-derived exosomes are emerging contributors to tumorigenesis. To …

Hereditary gastrointestinal (GI) cancer syndromes due to specific germline mutations are
characterized by an increased risk of GI tract malignancies, extra–GI tract cancers, and …

Background Previous studies have indicated that there may be a difference in tumor biology
between intraductal papillary mucinous carcinoma (IPMC) and pancreatic ductal …

The SMAD4 tumor suppressor gene product inhibits transforming growth factor-β-mediated
signaling and is mutated in~ 10% of colorectal carcinomas. The prognostic significance of …

Objectives The aims of this study were to identify genetic characteristics of intraductal
papillary mucinous neoplasm (IPMN)-associated pancreatic ductal carcinoma (PDC) and to …