Sensitivity of transcription factors to DNA methylation
Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …
states throughout organism development. Epigenetics modifications, such as DNA …
[HTML][HTML] Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis
Advances in genomic technology have enabled a greater understanding of the genetics of
common immune-mediated diseases such as ankylosing spondylitis (AS), inflammatory …
common immune-mediated diseases such as ankylosing spondylitis (AS), inflammatory …
TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells
KD Rasmussen, I Berest, S Keβler… - Genome …, 2019 - genome.cshlp.org
The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations
have been shown to arise in hematopoietic stem cells early in disease development and …
have been shown to arise in hematopoietic stem cells early in disease development and …
[HTML][HTML] Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
Polycomb group (PcG) proteins play critical roles in the epigenetic inheritance of cell fate.
The Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin …
The Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin …
[HTML][HTML] Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 …
Background Folate and vitamin B-12 are essential micronutrients involved in the donation of
methyl groups in cellular metabolism. However, associations between intake of these …
methyl groups in cellular metabolism. However, associations between intake of these …
CG dinucleotides enhance promoter activity independent of DNA methylation
Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in
CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is …
CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is …
[HTML][HTML] DNA methylation in mice is influenced by genetics as well as sex and life experience
DNA methylation is an essential epigenetic process in mammals, intimately involved in gene
regulation. Here we address the extent to which genetics, sex, and pregnancy influence …
regulation. Here we address the extent to which genetics, sex, and pregnancy influence …
Identification of DNA motifs that regulate DNA methylation
DNA methylation is an important epigenetic mark but how its locus-specificity is decided in
relation to DNA sequence is not fully understood. Here, we have analyzed 34 diverse whole …
relation to DNA sequence is not fully understood. Here, we have analyzed 34 diverse whole …
Unique DNA Methylation Profiles Are Associated with cis-Variation in Honey Bees
DNA methylation is an important epigenetic modification that mediates diverse processes
such as cellular differentiation, phenotypic plasticity, and genomic imprinting. Mounting …
such as cellular differentiation, phenotypic plasticity, and genomic imprinting. Mounting …
[HTML][HTML] Temporal Dynamics of DNA Methylation Patterns in Response to Rearing Juvenile Steelhead (Oncorhynchus mykiss) in a Hatchery versus Simulated Stream …
Genetic selection is often implicated as the underlying cause of heritable phenotypic
differences between hatchery and wild populations of steelhead trout (Oncorhynchus …
differences between hatchery and wild populations of steelhead trout (Oncorhynchus …