Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
Inflammation and fibrosis in murine models of heart failure
L Bacmeister, M Schwarzl, S Warnke, B Stoffers… - Basic research in …, 2019 - Springer
Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …
Targeting cell signaling in allergic asthma
SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …
[HTML][HTML] Phosphoinositide interactions position cGAS at the plasma membrane to ensure efficient distinction between self-and viral DNA
The presence of DNA in the cytosol of mammalian cells is an unusual event that is often
associated with genotoxic stress or viral infection. The enzyme cGAS is a sensor of cytosolic …
associated with genotoxic stress or viral infection. The enzyme cGAS is a sensor of cytosolic …
Engineering patient-specific cancer immunotherapies
Research into the immunological processes implicated in cancer has yielded a basis for the
range of immunotherapies that are now considered the fourth pillar of cancer treatment …
range of immunotherapies that are now considered the fourth pillar of cancer treatment …
Global virus outbreaks: Interferons as 1st responders
BX Wang, EN Fish - Seminars in immunology, 2019 - Elsevier
Outbreaks of severe virus infections with the potential to cause global pandemics are
increasing. In many instances these outbreaks have been newly emerging (SARS …
increasing. In many instances these outbreaks have been newly emerging (SARS …
Severe influenza pneumonitis in children with inherited TLR3 deficiency
HK Lim, SXL Huang, J Chen, G Kerner… - Journal of Experimental …, 2019 - rupress.org
Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and
underlie severe influenza pneumonitis. We report three unrelated children with influenza A …
underlie severe influenza pneumonitis. We report three unrelated children with influenza A …
How mRNA therapeutics are entering the monoclonal antibody field
L Van Hoecke, K Roose - Journal of Translational Medicine, 2019 - Springer
In 1975, Milstein and Köhler revolutionized the medical world with the development of the
hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies …
hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies …
[HTML][HTML] TLR8 is a sensor of RNase T2 degradation products
TLR8 is among the highest-expressed pattern-recognition receptors in the human myeloid
compartment, yet its mode of action is poorly understood. TLR8 engages two distinct ligand …
compartment, yet its mode of action is poorly understood. TLR8 engages two distinct ligand …
Azithromycin protects against Zika virus infection by upregulating virus-induced type I and III interferon responses
C Li, S Zu, YQ Deng, D Li, K Parvatiyar… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Azithromycin (AZM) is a widely used antibiotic, with additional antiviral and anti-inflammatory
properties that remain poorly understood. Although Zika virus (ZIKV) poses a significant …
properties that remain poorly understood. Although Zika virus (ZIKV) poses a significant …