The WHO 2007 glioma classification system (based primarily on tumour histology) resulted
in considerable interobserver variability and substantial variation in patient survival within …

Telomeres are nucleoprotein structures that cap the end of each chromosome arm and
function to maintain genome stability. The length of telomeres is known to shorten with each …

Background Two-sample summary-data Mendelian randomization (MR) incorporating
multiple genetic variants within a meta-analysis framework is a popular technique for …

Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans.
In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal …

Background Age is one of the strongest predictors of cancer, chronic disease, and mortality,
but biological responses to aging differ among people. Epigenetic DNA modifications have …

The distribution of telomere length in humans is broad, but it has finite upper and lower
boundaries. Growing evidence shows that there are disease processes that are caused by …

Inherited genetic variation influencing leukocyte telomere length provides a natural
experiment for testing associations with health outcomes, more robust to confounding and …

Genetic factors underlying leukocyte telomere length (LTL) may provide insights into
telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of …

Osteosarcoma is the most common primary tumor of bone. Osteosarcomas are rare in
humans, but occur more commonly in dogs. A comparative approach to studying …

Both theoretical and empirical work support the notion that meditation training can improve
telomere regulation, which may ultimately contribute to healthy aging. Yet, the psychological …