Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

Abstract Background 22q11. 2 deletion syndrome (22q11DS), a copy number variation
(CNV) disorder, occurs in approximately 1: 4000 live births due to a heterozygous …

SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice
carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations …

Copy-number variants of the CYFIP1 gene in humans have been linked to autism spectrum
disorders (ASD) and schizophrenia (SCZ), two neuropsychiatric disorders characterized by …

Neurodevelopmental disorders offer insight into synaptic mechanisms. To unbiasedly
uncover these mechanisms, we studied the 22q11. 2 syndrome, a recurrent copy number …

Biologic function of the majority of microRNAs (miRNAs) is still unknown. Uncovering the
function of miRNAs is hurdled by redundancy among different miRNAs. The deletion of …

The diagnosis of schizophrenia rests on clinical criteria that cannot be assessed in animal
models. Together with absence of a clear underlying pathology and understanding of what …

Heart failure is a worldwide leading cause of death. Diet and obesity are particularly of high
concern in heart disease etiology. Gravely, altered nutrition during developmental windows …

Homeostatic plasticity is a form of plasticity in which neurons compensate for changes in
neuronal activity through the control of key physiological parameters such as the number …

Small non-coding RNAs (sncRNAs), including microRNAs (miRNAs) are important post-
transcriptional gene expression regulators relevant in physiological and pathological …