Objective Osteoarthritis (OA) appears to be associated with various metabolic disorders, but
the potential contribution of amino acid metabolism to OA pathogenesis has not been clearly …

The zonal property of articular cartilage endows the tissue with biphasic mechanical
properties to withstand shearing force and compressional loading. Current treatments for …

Protein kinase casein kinase 2 (CK2) is important in the regulation of cell proliferation and
death, even under pathological conditions. Previously, we reported that CK2 regulates the …

It is well established that cells sense and respond to stimuli at the sub-micron and
nanometre scale, a factor that must be considered in future biomaterial design. The …

This thesis describes the development of a new class of biomimetic scaffolds for tissue
engineering of glandular organs and tumor tissue. Current tissue engineering strategies do …