Reactive oxygen species (ROS) are common by‐products of normal aerobic cellular
metabolism and play important physiological roles in intracellular cell signaling and …

Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …

Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

Nrf2 is a transcription factor that stimulates the expression of genes which have antioxidant
response element-like sequences in their promoter. Nrf2 is a cellular protector, and this …

High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here, we
unravel an unanticipated metabolic heterogeneity in HGSOC. By combining proteomic …

Regulation of antioxidant gene expression is essential for controlling oxidative stress and
maintaining physiological homeostasis. In this context, the nuclear factor E2-related factor 2 …

Several pharmacological, dietary, and genetic interventions that increase mammalian
lifespan are known, but general principles of lifespan extension remain unclear. Here, we …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a powerful nuclear transcription factor that
coordinates an antioxidant cytoprotector system complex stimulated by the increase in …

Reactive oxygen species (ROS) are chemically active free radicals produced by partial
reduction of oxygen that can activate discrete signaling pathways or disrupt redox …