Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

Abstract Iron deficiency anemia affects> 1.2 billions individuals worldwide, and iron
deficiency in the absence of anemia is even more frequent. Total-body (absolute) iron …

Ferroptosis is a novel form of programmed cell death in which the accumulation of
intracellular iron promotes lipid peroxidation, leading to cell death. Recently, the induction of …

Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic
materials to lysosomes via autophagosomes. Recent advances have enabled identification …

Immunometabolism explores how the intracellular metabolic pathways in immune cells can
regulate their function under different micro-environmental and (patho-)-physiological …

Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron …

Duality of iron as an essential cofactor of many enzymatic metabolic processes and as a
catalyst of poorly controlled redox-cycling reactions defines its possible biological beneficial …

Autophagy is an evolutionarily conserved lysosome-or vacuole-dependent catabolic
pathway in eukaryotes. Autophagy functions basally for cellular quality control and is …

Overexpression of myo-inositol oxygenase (MIOX), a proximal tubular enzyme, exacerbates
cellular redox injury in acute kidney injury (AKI). Ferroptosis, a newly coined term associated …

NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of
ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in …