The endoplasmic reticulum aminopeptidases (ERAPs), ERAP1 and ERAP2, makes a role in
shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I …

Patients with Behçet's disease (BD) suffer from episodic ocular and mucocutaneous attacks,
resulting in a reduced quality of life. The phenotype of Japanese BD has been changing …

Psoriasis is an inflammatory skin disease with a background of polygenic inheritance. Both
environmental and genetic factors are involved in the etiology of the disease. In the last two …

Bacterial RNA has emerged as an important activator of innate immune responses by
stimulating Toll-like receptors TLR7 and TLR8 in humans. Guanosine 2′-O-methylation at …

Psoriasis is multifactorial disease with complex genetic predisposition. Recent advances in
genetics and genomics analyses have provided many insights into the relationship between …

Background Methotrexate (MTX) is an efficacious treatment for psoriasis; however, its
widespread application is limited by its unpredictable efficacy. Objectives To investigate the …

Genetic studies based on single-nucleotide polymorphisms have provided valuable insights
into the genetic architecture of complex diseases. However, a large fraction of heritability for …

Background. The hypoxic conditions at high altitudes are great threats to survival, causing
pressure for adaptation. More and more high‐altitude denizens are not adapted with the …

Many common diseases are characterized by polygenic architectures in which a single
variant has only a small effect on phenotype. Genome-wide association studies and next …

1. Glándula tiroides __________________________________… 1 1.1. Estructura__________________________…
1 1.2. Síntesis, almacenamiento y liberación de las hormonas tiroideas_________ 3 1.3 …