Normalizing function of tumor vessels: progress, opportunities, and challenges
Abnormal blood and lymphatic vessels create a hostile tumor microenvironment
characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These …
characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These …
Fibroblasts fuel immune escape in the tumor microenvironment
EA De Jaeghere, HG Denys, O De Wever - Trends in cancer, 2019 - cell.com
Immune escape is central to the persistence of most, if not all, solid tumors and poses a
critical obstacle to successful cancer (immuno) therapy. Cancer-associated fibroblasts …
critical obstacle to successful cancer (immuno) therapy. Cancer-associated fibroblasts …
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
Cancer cell metabolism is heavily influenced by microenvironmental factors, including
nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential …
nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential …
Total neoadjuvant therapy with FOLFIRINOX in combination with losartan followed by chemoradiotherapy for locally advanced pancreatic cancer: a phase 2 clinical …
JE Murphy, JY Wo, DP Ryan, JW Clark, W Jiang… - JAMA …, 2019 - jamanetwork.com
Importance Patients with locally advanced pancreatic cancer have historically poor
outcomes. Evaluation of a total neoadjuvant approach is warranted. Objective To evaluate …
outcomes. Evaluation of a total neoadjuvant approach is warranted. Objective To evaluate …
Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer
IX Chen, VP Chauhan, J Posada… - Proceedings of the …, 2019 - National Acad Sciences
Metastatic breast cancers (mBCs) are largely resistant to immune checkpoint blockade, but
the mechanisms remain unclear. Primary breast cancers are characterized by a dense …
the mechanisms remain unclear. Primary breast cancers are characterized by a dense …
Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma
In ovarian cancer patients, tumor fibrosis and angiotensin-driven fibrogenic signaling have
been shown to inversely correlate with survival. We sought to enhance drug delivery and …
been shown to inversely correlate with survival. We sought to enhance drug delivery and …
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy
Cancer-associated fibroblasts (CAFs) can either suppress or support T lymphocyte activity,
suggesting that CAFs may be reprogrammable to an immunosupportive state. Angiotensin …
suggesting that CAFs may be reprogrammable to an immunosupportive state. Angiotensin …
[HTML][HTML] Reprogramming the tumor microenvironment to improve immunotherapy: emerging strategies and combination therapies
Emerging immunotherapeutic approaches have revolutionized the treatment of multiple
malignancies. Ime-mune checkpoint blockers (ICBs) have enabled never-before-seen …
malignancies. Ime-mune checkpoint blockers (ICBs) have enabled never-before-seen …
Programmed cell death protein‐1 (PD‐1)‐targeted immunotherapy in advanced hepatocellular carcinoma: efficacy and safety data from an international multicentre …
B Scheiner, MM Kirstein, F Hucke… - Alimentary …, 2019 - Wiley Online Library
Background Programmed cell death protein‐1‐targeted immunotherapy has shown
promising results in phase II studies of hepatocellular carcinoma. Aim To evaluate safety …
promising results in phase II studies of hepatocellular carcinoma. Aim To evaluate safety …