Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of …

Tau protein aggregation into neurofibrillary tangles in the central nervous system contributes
to the etiology of certain neurodegenerative disorders, including Alzheimer's disease (AD) …

Lysine methylation is well-documented and relatively well-understood with respect to
histone modification and the epigenetic regulation of gene expression. Enzymes called …

Filamentous aggregates (fibrils) are regarded as the final stage in the assembly of
amyloidogenic proteins and are formed in many neurodegenerative diseases. Accumulation …

Tau is a microtubule-associated protein that normally interacts in monomeric form with the
neuronal cytoskeleton. In Alzheimer's disease, however, it aggregates to form the structural …

Multiple neurodegenerative conditions including Alzheimer's disease and frontotemporal
dementia are characterized by the accumulation of tau in the brain, associated with synapse …

The roles of post-translational modifications (PTMs) in the onset and progression of disease
have been extensively studied for decades. More specifically, various PTMs have been the …

The molecular events underlying the transition from initial inflammatory flares to the
progressive phase of multiple sclerosis (MS) remain poorly understood. Here, we report that …

Les dépôts intracellulaires de la protéine Tau agrégée sont la caractéristique commune des
tauopathies, une famille de maladies neurodégénératives dont fait partie la maladie …